Author's response to reviews Title: Augmentation Index and Proximal Aortic Stiffness In Bicuspid Aortic Valve Patients with Non-Dilated Proximal Aortas Authors:

Augmentation index and aortic stiffness in bicuspid aortic valve patients with non-dilated proximal aortas

BACKGROUND We compared aortic stiffness, aortic impedance and pressure from wave reflections in the setting of bicuspid aortic valve (BAV) to the tricuspid aortic valve (TAV) in the absence of proximal aortic dilation. We hypothesized BAV is associated with abnormal arterial stiffness. METHODS Ten BAV subjects (47 ± 4 years, 6 male) and 13 TAV subjects (46 ± 4 years, 10 male) without signific...

Endothelial function, carotid-femoral stiffness, and plasma matrix metalloproteinase-2 in men with bicuspid aortic valve and dilated aorta.

OBJECTIVES This study sought to examine the relationship between proximal aortic dilation and systemic vascular function in men with bicuspid aortic valve (BAV). BACKGROUND Proximal aortic dilation in subjects with BAV is associated with structural and functional abnormalities in the ascending aorta. METHODS We studied 32 men (median age 31 years [range 28 to 32 years]) with nonstenotic BAV...

Bicuspid Aortic Valve: An Unusual Cause of Aneurysm of Left Coronary Sinus of Valsalva

Bicuspid aortic valve is traditionally considered an innocuous congenital anomaly. Due to a better and widespread availability of non-invasive imaging techniques, it has come to the fore that 30% of these cases develop complications, viz., valve abnormality (aortic regurgitation and stenosis), and aneurysm of aortic root and ascending aorta. Sinus of Valsalva aneurysm is an uncommon complicatio...

Author's response to reviews Title: Sequencing of NOTCH1, GATA5, TGFBRI AND TGFBRII genes in familial cases of Bicuspid Aortic Valve Authors:

Aortic Cross-Sectional Area/Height Ratio and Outcomes in Patients With Bicuspid Aortic Valve and a Dilated Ascending Aorta.

BACKGROUND In patients with bicuspid aortic valve and dilated proximal ascending aorta, we sought to assess (1) factors associated with increased longer-term cardiovascular mortality and (2) incremental prognostic use of indexing aortic root to patient height. METHODS AND RESULTS We studied 969 consecutive bicuspid aortic valve patients (50±13 years; 87% men) with proximal aorta ≥4 cm, who al...